No drivers from epson, but I found this thread
http://www.w7forums.com/windows-7-64-bit-driver-epson-perfection-1650-photo-scanner-t3459.html
which lead here http://uploading.com/files/get/3214affd/.
Yes they’re the drivers for the 1650 in vista x64 (yikes)
open device manager, click on the ! device. Right click and chose “update driver”
Browse >let me pick from a list> have disk
find the ES27.inf and install. I’ve only run it so far from the “Epson Scan” Utility – no twain support. It saves a jpeg into you “my pictures” folder
Its time for a new scanner, but this will keep me limping along