No drivers from epson, but I found this thread
http://www.w7forums.com/windows-7-64-bit-driver-epson-perfection-1650-photo-scanner-t3459.html
which lead here http://uploading.com/files/get/3214affd/.
Yes they’re the drivers for the 1650 in vista x64 (yikes)
open device manager, click on the ! device. Right click and chose “update driver”
Browse >let me pick from a list> have disk
find the ES27.inf and install. I’ve only run it so far from the “Epson Scan” Utility – no twain support. It saves a jpeg into you “my pictures” folder
Its time for a new scanner, but this will keep me limping along
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I also had the same issue with my scanner on Vista x64. I found the drivers for the Epson Perfection 4990 PHOTO work just fine.
Install the drivers normally, turn on the scanner, go to Device Manager, and manually select the 4990 driver.
The driver can be found here: http://www.epson.com/cgi-bin/Store/support/supDetail.jsp?oid=50666&prodoid=49164280&BV_UseBVCookie=yes&infoType=Downloads&platform=Windows64&x=21&y=15